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Biology of hypoxia-inducible factor-2alpha in development and disease Patel SA; Simon MCCell Death Differ 2008[Apr]; 15 (4): 628-34The transcriptional response to hypoxia is primarily mediated by two hypoxia-inducible factors--HIF-1alpha and HIF-2alpha. While these proteins are highly homologous, increasing evidence suggests they have unique transcriptional targets and differential impact on tumor growth. Furthermore, non-transcriptional effects of the HIF-alpha subunits, including effects on the Notch and c-Myc pathways, contribute to their distinct functions. HIF-2alpha transcriptional targets include genes involved in erythropoiesis, angiogenesis, metastasis, and proliferation. Therefore, HIF-2alpha contributes significantly to both normal physiology as well as tumorigenesis. Here, we summarize the function of HIF-2alpha during development as well as its contribution to pathologic conditions, such as tumors and vascular disease.|*Signal Transduction[MESH]|Animals[MESH]|Basic Helix-Loop-Helix Transcription Factors/genetics/*metabolism[MESH]|Cell Hypoxia[MESH]|Cell Transformation, Neoplastic/metabolism[MESH]|Gene Expression Regulation, Neoplastic[MESH]|Genotype[MESH]|Humans[MESH]|Hypoxia/genetics/*metabolism[MESH]|Mice[MESH]|Mice, Knockout[MESH]|Neoplasms/genetics/*metabolism[MESH]|Phenotype[MESH]|Tissue Distribution[MESH]|Transcription, Genetic[MESH] |