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Mammalian DNA methyltransferases: a structural perspective Cheng X; Blumenthal RMStructure 2008[Mar]; 16 (3): 341-50The methylation of mammalian DNA, primarily at CpG dinucleotides, has long been recognized to play a major role in controlling gene expression, among other functions. Given their importance, it is surprising how many basic questions remain to be answered about the proteins responsible for this methylation and for coordination with the parallel chromatin-marking system that operates at the level of histone modification. This article reviews recent studies on, and discusses the resulting biochemical and structural insights into, the DNA nucleotide methyltransferase (Dnmt) proteins 1, 3a, 3a2, 3b, and 3L.|Amino Acid Sequence[MESH]|Animals[MESH]|CpG Islands/physiology[MESH]|DNA Methylation[MESH]|DNA Modification Methylases/*chemistry[MESH]|Dimerization[MESH]|Humans[MESH]|Mammals[MESH]|Models, Biological[MESH]|Models, Molecular[MESH]|Molecular Sequence Data[MESH]|Sequence Homology, Amino Acid[MESH] |
