Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
The role of palladin in actin organization and cell motility Goicoechea SM; Arneman D; Otey CAEur J Cell Biol 2008[Sep]; 87 (8-9): 517-25Palladin is a widely expressed protein found in stress fibers, focal adhesions, growth cones, Z-discs, and other actin-based subcellular structures. It belongs to a small gene family that includes the Z-disc proteins myopalladin and myotilin, all of which share similar Ig-like domains. Recent advances have shown that palladin shares with myotilin the ability to bind directly to F-actin, and to crosslink actin filaments into bundles, in vitro. Studies in a variety of cultured cells suggest that the actin-organizing activity of palladin plays a central role in promoting cell motility. Correlative evidence also supports this hypothesis, as palladin levels are typically up-regulated in cells that are actively migrating: in developing vertebrate embryos, in cells along a wound edge, and in metastatic cancer cells. Recently, a mutation in the human palladin gene was implicated in an unusually penetrant form of inherited pancreatic cancer, which has stimulated new ideas about the role of palladin in invasive cancer.|Actin Cytoskeleton/physiology/*ultrastructure[MESH]|Animals[MESH]|Cell Adhesion Molecules/metabolism[MESH]|Cell Movement/*physiology[MESH]|Cytoskeletal Proteins/genetics/metabolism[MESH]|Cytoskeleton/metabolism[MESH]|Humans[MESH]|Microfilament Proteins/genetics/*physiology[MESH]|Models, Biological[MESH]|Mutation[MESH]|Phosphoproteins/genetics/metabolism[MESH]|Transforming Growth Factor beta1/metabolism[MESH]|Wound Healing/physiology[MESH] |
