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Staying alive: bacterial inhibition of apoptosis during infection Faherty CS; Maurelli ATTrends Microbiol 2008[Apr]; 16 (4): 173-80The ability of bacterial pathogens to inhibit apoptosis in eukaryotic cells during infection is an emerging theme in the study of bacterial pathogenesis. Prevention of apoptosis provides a survival advantage because it enables the bacteria to replicate inside host cells. Bacterial pathogens have evolved several ways to prevent apoptosis by protecting the mitochondria and preventing cytochrome c release, by activating cell survival pathways, or by preventing caspase activation. This review summarizes the most recent work on bacterial anti-apoptotic strategies and suggests new research that is necessary to advance the field.|*Apoptosis[MESH]|*Host-Pathogen Interactions[MESH]|Animals[MESH]|Bacteria/*growth & development/*pathogenicity[MESH]|Bacterial Infections/microbiology[MESH]|Caspase Inhibitors[MESH]|Caspases/metabolism[MESH]|Cell Line[MESH]|Cytochromes c/antagonists & inhibitors/metabolism[MESH]|Eukaryotic Cells/*microbiology/physiology[MESH]|Humans[MESH]|Mitochondria/physiology[MESH]|Rats[MESH] |
