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Gene regulation by transcription factors and microRNAs Hobert OScience 2008[Mar]; 319 (5871): 1785-6The properties of a cell are determined by the genetic information encoded in its genome. Understanding how such information is differentially and dynamically retrieved to define distinct cell types and cellular states is a major challenge facing molecular biology. Gene regulatory factors that control the expression of genomic information come in a variety of flavors, with transcription factors and microRNAs representing the most numerous gene regulatory factors in multicellular genomes. Here, I review common principles of transcription factor- and microRNA-mediated gene regulatory events and discuss conceptual differences in how these factors control gene expression.|*Gene Expression Regulation[MESH]|*Gene Regulatory Networks[MESH]|Animals[MESH]|MicroRNAs/genetics/*metabolism[MESH]|Phenotype[MESH]|Transcription Factors/*metabolism[MESH]|Transcription, Genetic[MESH] |
