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Arterial spin-labeling in routine clinical practice, part 1: technique and artifacts Deibler AR; Pollock JM; Kraft RA; Tan H; Burdette JH; Maldjian JAAJNR Am J Neuroradiol 2008[Aug]; 29 (7): 1228-34The routine use of arterial spin-labeling (ASL) in a clinical population has led to the depiction of diverse brain pathologic features. Unique challenges in the acquisition, postprocessing, and analysis of cerebral blood flow (CBF) maps are encountered in such a population, and high-quality ASL CBF maps can be generated consistently with attention to quality control and with the use of a dedicated postprocessing pipeline. Familiarity with commonly encountered artifacts can help avoid pitfalls in the interpretation of CBF maps. The purpose of this review was to describe our experience with a heterogeneous collection of ASL perfusion cases with an emphasis on methodology and common artifacts encountered with the technique. In a period of 1 year, more than 3000 pulsed ASL cases were performed as a component of routine clinical brain MR evaluation at both 1.5 and 3T. These ASL studies were analyzed with respect to overall image quality and patterns of perfusion on final gray-scale DICOM images and color Joint Photographic Experts Group (JPEG) CBF maps, and common artifacts and their impact on final image quality were categorized.|Adolescent[MESH]|Adult[MESH]|Age Factors[MESH]|Artifacts[MESH]|Blood Flow Velocity/physiology[MESH]|Brain/*blood supply[MESH]|Child[MESH]|Child, Preschool[MESH]|Humans[MESH]|Image Enhancement/*methods[MESH]|Image Processing, Computer-Assisted/*methods[MESH]|Infant[MESH]|Infant, Newborn[MESH]|Magnetic Resonance Angiography/*methods[MESH]|Reference Values[MESH]|Regional Blood Flow/physiology[MESH]|Sensitivity and Specificity[MESH]|Software Design[MESH] |
