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Advances in understanding the anti-inflammatory properties of IL-27 Stumhofer JS; Hunter CAImmunol Lett 2008[May]; 117 (2): 123-30Initial studies on the biology of IL-27 provided evidence of a role for this cytokine in the initiation of Th1 responses; however, subsequent work using models of pathogen-induced and autoimmune inflammation have indicated that IL-27 has broad inhibitory effects on Th1, Th2 and Th17 subsets of T cells as well as the expansion of inducible regulatory T cells. While, the aim of this review is to highlight the functions of IL-27 in the context of inflammation it will also serve to elaborate on the molecular mechanisms involved in the production of this cytokine. The initial description of IL-27 indicated that classical antigen-presenting cells such as macrophages and dendritic cells produce IL-27, however, the agonists and signaling pathways involved in activating transcription of the two subunits of IL-27, p28 and EBV-induced gene 3 (EBI3) have only recently been described.|*Interleukin-17/biosynthesis/immunology/metabolism[MESH]|Animals[MESH]|Autoimmune Diseases/immunology[MESH]|Bacterial Infections/immunology/metabolism[MESH]|CD4-Positive T-Lymphocytes/immunology/metabolism[MESH]|Feedback, Physiological/immunology[MESH]|Humans[MESH]|Inflammation/immunology/microbiology[MESH]|Interleukin-10/metabolism[MESH]|Interleukins/biosynthesis/*immunology[MESH]|Lymphocyte Activation[MESH]|MAP Kinase Signaling System/immunology[MESH]|Minor Histocompatibility Antigens[MESH]|T-Lymphocyte Subsets/immunology/metabolism[MESH]|Toll-Like Receptor 4/immunology/metabolism[MESH] |
