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Cancer: inappropriate expression of stem cell programs?Wang Y; Armstrong SACell Stem Cell 2008[Apr]; 2 (4): 297-9Cancer stem cells (CSCs) are a subpopulation of cancer cells that possess characteristics, including self-renewal, associated with normal stem cells. In this issue of Cell Stem Cell, Wong et al. (2008) define a core embryonic stem cell (ESC)-like gene expression program that may be important for CSC function in multiple epithelial cancers.|*Transcription, Genetic[MESH]|Adult Stem Cells/cytology/*physiology[MESH]|Animals[MESH]|Biomarkers, Tumor/genetics/*metabolism[MESH]|Cell Transformation, Neoplastic[MESH]|Embryonic Stem Cells/cytology/*physiology[MESH]|Epithelium/*pathology[MESH]|Humans[MESH]|Neoplasms, Experimental/genetics/metabolism/*pathology[MESH]|Neoplastic Stem Cells/*pathology[MESH] |
