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C-Peptide and atherogenesis: C-Peptide as a mediator of lesion development in patients with type 2 diabetes mellitus?Marx N; Walcher DExp Diabetes Res 2008[]; 2008 (�): 385108Patients with insulin resistance and early type 2 diabetes exhibit an increased propensity to develop a diffuse and extensive pattern of arteriosclerosis. Typically, these patients show increased levels of C-peptide and over the last years various groups examined the effect of C-peptide in vascular cells as well as its potential role in lesion development. While some studies demonstrated beneficial effects of C-peptide, for example, by showing an inhibition of smooth muscle cell proliferation, others suggested proatherogenic mechanisms in patients with type 2 diabetes. Among them, C-peptide may facilitate the recruitment of inflammatory cells into early lesions and promote lesion progression by inducing smooth muscle cell proliferation. The following review will summarize the effects of C-peptide in vascular cells and discuss the potential role of C-peptide in atherogenesis in patients with type 2 diabetes.|Atherosclerosis/*blood[MESH]|C-Peptide/*blood[MESH]|Cell Division[MESH]|Chemotaxis, Leukocyte[MESH]|Diabetes Mellitus, Type 2/*blood[MESH]|Diabetic Angiopathies/*blood[MESH]|Humans[MESH]|Muscle, Smooth, Vascular/pathology/physiopathology[MESH] |