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Androgens in health and disease: an overview Jordan CL; Doncarlos LHorm Behav 2008[May]; 53 (5): 589-95This special issue of Hormones and Behavior, "Androgens in health and disease: new insights into roles and mechanisms of action," is prompted by a number of relatively recent findings that androgens affect brain morphology and function in ways not previously or widely appreciated. Moreover, recent results also make it clear that androgens utilize a variety of signaling molecules to exert their effects on the brain, which may or may not depend on the classic nuclear androgen receptor (AR). The papers in this issue underscore these two points. This overview is not intended as a comprehensive review of androgen action on the nervous system, since the papers in this issue serve that purpose, but rather to frame the basic issues and themes that tie these papers together. The sum effect of the stories told in this issue encourages us to broaden and refocus our view of androgen action on brain and behavior-to recognize that androgens affect many aspects of brain structure and function throughout the lifespan, from shaping its sexual phenotype to influencing its propensity for disease and repair, and that at least some of these actions are exerted via non-classical modes of action that in many cases were first identified in non-neural tissue or cells.|Androgens/*physiology[MESH]|Animals[MESH]|Disease[MESH]|Female[MESH]|Health[MESH]|Humans[MESH]|Male[MESH]|Nerve Degeneration/physiopathology[MESH]|Neurosecretory Systems/physiology[MESH]|Receptors, Androgen/physiology[MESH]|Sex Differentiation[MESH]|Social Behavior[MESH]|Testis/physiology[MESH] |
