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Immune intervention with monoclonal antibodies targeting CD152 (CTLA-4) for autoimmune and malignant diseases Chin LT; Chu C; Chen HM; Wang DW; Liao SKChang Gung Med J 2008[Jan]; 31 (1): 1-15CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy for over a decade. However, the precise roles played by this molecule continue to emerge. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg). In this review, we discuss the recent progress and main features of monoclonal antibodies (mAbs) targeting CD152 and examine how each mAb prepared to a distinct epitope may impact differently upon CD152 modulation depending on its demonstrated regulatory role acting as an agonist, antagonist, or inverse agonist.|Amino Acid Sequence[MESH]|Antibodies, Monoclonal/*therapeutic use[MESH]|Antigens, CD/chemistry/*physiology[MESH]|Antigens, Differentiation/chemistry/*physiology[MESH]|Autoimmune Diseases/immunology/*therapy[MESH]|B7-1 Antigen/physiology[MESH]|CD28 Antigens/physiology[MESH]|CTLA-4 Antigen[MESH]|Cell Adhesion[MESH]|Humans[MESH]|Molecular Sequence Data[MESH]|Neoplasms/immunology/*therapy[MESH]|Protein Conformation[MESH]|Signal Transduction[MESH]|T-Lymphocytes, Regulatory/physiology[MESH] |
