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Processing of Clostridium difficile toxins Giesemann T; Egerer M; Jank T; Aktories KJ Med Microbiol 2008[Jun]; 57 (Pt 6): 690-696The pathogenicity of Clostridium difficile depends on the large clostridial glucosylating toxins A and B (TcdA and TcdB). The proteins accomplish their own uptake by a modular structure comprising a catalytic and a binding/translocation domain. Based on a proteolytic processing step solely the catalytic domain reaches the cytosol. Within the cells, the glucosyltransferases inactivate small GTPases by mono-O-glucosylation. Here, a short overview is given regarding latest insights into the intramolecular processing, which is mediated by an intrinsic protease activity.|Amino Acid Sequence[MESH]|Bacterial Proteins/chemistry/*metabolism[MESH]|Bacterial Toxins/chemistry/*metabolism[MESH]|Clostridioides difficile/metabolism/*pathogenicity[MESH]|Enterotoxins/chemistry/*metabolism[MESH]|Molecular Sequence Data[MESH]|Virulence[MESH] |
