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Immune-mediated dormancy: an equilibrium with cancer Teng MW; Swann JB; Koebel CM; Schreiber RD; Smyth MJJ Leukoc Biol 2008[Oct]; 84 (4): 988-93This brief review discusses the role of the immune system in tumor development, covering a history of cancer immunity and a summary of the concept of cancer immunoediting, including its three phases: elimination, equilibrium, and escape. The latter half of this review then focuses specifically on the equilibrium phase, making note of previous work, suggesting that immunity might maintain cancer in a dormant state, and concluding with a description of a tractable mouse model unequivocally demonstrating that immunity can indeed hold preformed cancer in check. These findings form a framework for future studies aimed at validating immune-mediated cancer dormancy in humans with the hopes of devising new, immunotherapeutic strategies to treat established cancer.|*Immune System[MESH]|Animals[MESH]|Disease Models, Animal[MESH]|Humans[MESH]|Interferon-gamma/immunology[MESH]|Interleukin-12/immunology[MESH]|Mice[MESH]|Neoplasms/*immunology/*pathology[MESH]|Neovascularization, Pathologic/immunology[MESH]|T-Lymphocytes/immunology[MESH]|Tumor Escape/*immunology[MESH] |
