Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
The intricate interface between immune and metabolic regulation: a role for leptin in the pathogenesis of multiple sclerosis?Matarese G; Procaccini C; De Rosa VJ Leukoc Biol 2008[Oct]; 84 (4): 893-9Over the last few years, a series of molecules known to play a function in metabolism has also been shown to play an important role in the regulation of the immune response. In this context, the adipocyte-derived hormone leptin has been shown to regulate the immune response in normal as well as in pathological conditions. More specifically, it has been shown that conditions of reduced leptin production (i.e., genetic leptin deficiency, anorexia nervosa, malnutrition) are associated with increased susceptibility to infections. Conversely, immune-mediated disorders such as autoimmune disorders are associated with increased secretion of leptin and production of proinflammatory, pathogenic cytokines. Leptin could represent the "missing link" among immune response, metabolic function, and nutritional status. Indeed, more recently, leptin-deficient mice have been shown to be resistant to a series of experimentally induced autoimmune disorders including experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. Normal wild-type mice show increased secretion of leptin in serum upon EAE induction, and brain inflammatory infiltrates stain positive for leptin. Finally, leptin neutralization with leptin antagonists improves the EAE course by profoundly altering intracellular signaling of myelin-reactive T cells and increasing the number of regulatory forkhead/winged helix transcription factor 3(+)CD4(+) T cells. These data suggest that leptin can be considered as a link among immune tolerance, metabolic state, and autoimmunity and that strategies aimed at interfering with the leptin axis could represent innovative, therapeutic tools for autoimmune disorders.|Animals[MESH]|Autoimmune Diseases/immunology/*physiopathology[MESH]|Brain/physiopathology[MESH]|CD4-Positive T-Lymphocytes/immunology[MESH]|Encephalomyelitis, Autoimmune, Experimental/immunology[MESH]|Homeostasis/immunology/*physiology[MESH]|Humans[MESH]|Immunity[MESH]|Inflammation/immunology/*physiopathology[MESH]|Leptin/immunology/*physiology[MESH]|Metabolism[MESH]|Multiple Sclerosis/immunology/*physiopathology[MESH]|Obesity/immunology/physiopathology[MESH]|T-Lymphocytes, Regulatory/immunology[MESH] |
