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Kisspeptin and GPR54: discovery of a novel pathway in reproduction Seminara SB; Crowley WF JrJ Neuroendocrinol 2008[Jun]; 20 (6): 727-31In order to find novel modulators of gonadotrophin-releasing hormone (GnRH) secretion, genetic tools were employed in patients with idiopathic hypogonadotrophic hypogonadism (IHH). Mutations in a G-protein coupled receptor, GPR54, were identified, making this receptor a genetic determinant and indisputable gatekeeper of normal reproductive function. This article places these investigations into historical context and reviews some of the new findings relevant to this pathway.|Animals[MESH]|Gene Deletion[MESH]|Gonadotropin-Releasing Hormone/metabolism[MESH]|Heterotrimeric GTP-Binding Proteins/metabolism[MESH]|Humans[MESH]|Hypogonadism/genetics/metabolism[MESH]|Kisspeptins[MESH]|Puberty/physiology[MESH]|Receptors, G-Protein-Coupled/genetics/*metabolism[MESH]|Receptors, Kisspeptin-1[MESH]|Reproduction/*physiology[MESH]|Signal Transduction/*physiology[MESH]|Tumor Suppressor Proteins/genetics/*metabolism[MESH] |
