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MHC class I assembly: out and about Raghavan M; Del Cid N; Rizvi SM; Peters LRTrends Immunol 2008[Sep]; 29 (9): 436-43The assembly of major histocompatibility complex (MHC) class I molecules with peptides is orchestrated by several assembly factors including the transporter associated with antigen processing (TAP) and tapasin, the endoplasmic reticulum (ER) oxido-reductases ERp57 and protein disulfide isomerase (PDI), the lectin chaperones calnexin and calreticulin, and the ER aminopeptidase (ERAAP). Typically, MHC class I molecules present endogenous antigens to cytotoxic T lymphocytes (CTLs). However, the initiation of CD8(+) T-cell responses against many pathogens and tumors also requires the presentation of exogenous antigens by MHC class I molecules. We discuss recent developments relating to interactions and mechanisms of function of the various assembly factors and pathways by which exogenous antigens access MHC class I molecules.|ATP-Binding Cassette Transporters/immunology/metabolism[MESH]|Animals[MESH]|Antigen Presentation/*immunology[MESH]|Cross-Priming/immunology[MESH]|Histocompatibility Antigens Class I/*immunology/metabolism[MESH]|Humans[MESH]|Leucyl Aminopeptidase/immunology/metabolism[MESH]|Membrane Transport Proteins/immunology/metabolism[MESH]|Models, Immunological[MESH]|Peptides/immunology/metabolism[MESH] |
