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lüll Degenerescence maculaire liee a l'age et genetique: donnees actuelles Fajnkuchen F; Cohen SYJ Fr Ophtalmol 2008[Jun]; 31 (6 Pt 1): 630-7The relationship between genetics and age-related macular degeneration is well established. Heritability has been estimated to be up to 70%. Recent studies have identified several chromosomal regions that are likely to contain susceptibility loci. Common variations in three genes (CFH, LOC 387715 and C2-FB) strongly influence the risk of age-related macular degeneration. New findings in the field of the genetics of age-related macular degeneration are a starting point toward understanding the causes of AMD and for future therapeutic studies.|Age of Onset[MESH]|Aged[MESH]|Aged, 80 and over[MESH]|Case-Control Studies[MESH]|Chromosome Mapping[MESH]|Complement C2/genetics[MESH]|Complement Factor B/genetics[MESH]|Complement Factor H/genetics/physiology[MESH]|Complement Pathway, Alternative[MESH]|Environmental Exposure[MESH]|Epigenesis, Genetic[MESH]|Female[MESH]|Genetic Heterogeneity[MESH]|Genetic Predisposition to Disease[MESH]|Genotype[MESH]|High-Temperature Requirement A Serine Peptidase 1[MESH]|Humans[MESH]|Intracellular Signaling Peptides and Proteins/genetics[MESH]|Linkage Disequilibrium[MESH]|Macular Degeneration/epidemiology/etiology/*genetics/therapy[MESH]|Male[MESH]|Membrane Proteins/genetics[MESH]|Middle Aged[MESH]|Mutation, Missense[MESH]|Polymorphism, Single Nucleotide[MESH]|Proteins/genetics[MESH]|Serine Endopeptidases/genetics[MESH] |