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Transcriptional regulation of lymphocyte development Dias S; Xu W; McGregor S; Kee BCurr Opin Genet Dev 2008[Oct]; 18 (5): 441-8B lymphocytes and T lymphocytes develop from hematopoietic stem cells through a series of intermediates with progressively decreased lineage differentiation potential. Differentiation is preceded by increased accessibility of the chromatin at genes that are poised for expression in the progeny of a multipotent cell. During the process of differentiation there is increased expression of lineage-associated genes and repression of lineage-inappropriate genes resulting in commitment to differentiation through a specific lineage. These transcriptional events are coordinated by networks of transcription factors and their associated chromatin remodeling factors. The B lymphocyte lineage provides a paradigm for how these events unfold to promote specification and commitment to a single developmental pathway.|*Gene Expression Regulation, Developmental[MESH]|Cell Differentiation/*genetics[MESH]|Cell Lineage[MESH]|Hematopoietic Stem Cells/*cytology/metabolism[MESH]|Lymphocytes/*cytology/metabolism[MESH]|Models, Genetic[MESH]|Transcription Factors/metabolism/physiology[MESH]|Transcription, Genetic[MESH] |
