Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
IDO: a double-edged sword for T(H)1/T(H)2 regulation Xu H; Zhang GX; Ciric B; Rostami AImmunol Lett 2008[Nov]; 121 (1): 1-6Indoleamine 2,3-dioxygenase (IDO) has been well defined as one of the important immunosuppressive properties for T(H)1 cell-mediated immune responses, but its function in T(H)2 dominant system is poorly understood. Recently, an appreciable number of publications suggest that the role of IDO in T(H)2 cell regulation may be different from that of T(H)1 immune responses. Here we review the evidence on the regulatory function of IDO and tryptophan metabolites in T(H)1/T(H)2 differentiation. We propose that IDO-kynurenine pathway can serve as a negative feedback loop for T(H)1 cells but it may play a distinct role in up-regulating T(H)2 dominant immune responses.|Animals[MESH]|Cell Differentiation[MESH]|Dendritic Cells/immunology/metabolism[MESH]|Humans[MESH]|Indoleamine-Pyrrole 2,3,-Dioxygenase/deficiency/*immunology/metabolism[MESH]|Interferon-gamma/immunology/*metabolism[MESH]|Kynurenine/immunology/metabolism[MESH]|Th1 Cells/enzymology/*immunology[MESH]|Th2 Cells/enzymology/*immunology[MESH]|Toll-Like Receptors/immunology/metabolism[MESH]|Tryptophan/immunology/metabolism[MESH]|Up-Regulation[MESH] |
