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Melatonin and its agonists: an update Arendt J; Rajaratnam SMBr J Psychiatry 2008[Oct]; 193 (4): 267-9The pineal hormone melatonin is able to shift the timing of circadian rhythms, including the sleep-wake cycle, and to promote sleep. Melatonin agonists with similar properties have therapeutic potential for the treatment of circadian rhythm sleep disorders. Depression is specifically targeted by agomelatine, which is also a serotonin-2C (5-HT(2C)) antagonist.|*Melatonin/agonists/physiology/therapeutic use[MESH]|Acetamides/administration & dosage[MESH]|Benzofurans/administration & dosage[MESH]|Cyclopropanes/administration & dosage[MESH]|Drug Administration Schedule[MESH]|Humans[MESH]|Indenes/administration & dosage[MESH]|Receptors, Melatonin/*antagonists & inhibitors[MESH] |
