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Integrating functional brain neuroimaging and developmental cognitive neuroscience in child psychiatry research Pavuluri MN; Sweeney JAJ Am Acad Child Adolesc Psychiatry 2008[Nov]; 47 (11): 1273-88OBJECTIVE: To provide an overview of clinical research aiming to develop a mechanistic understanding of brain dysfunction in child psychiatric disorders. METHOD: Technological, conceptual, and translational approaches relevant to the investigation of brain function in pediatric psychiatric illnesses are explored. Research in the area of pediatric bipolar disorder is used as a prototypic model illustrating the use of complementary techniques of functional magnetic neuroimaging and neurocognitive studies to identify abnormalities in neural circuitry function. RESULTS: Studies of bipolar youths indicate impairment in cognitive and affective neural systems and in the interface of these two circuits. This evolving field paves a future pathway for identifying diagnostic biomarkers for the disorder, providing tools for monitoring response to pharmacotherapy, examining illness-associated alterations in developmental trajectory, and facilitating the use of animal research for guiding the development of novel treatment strategies. CONCLUSIONS: Studies of brain function in child psychiatry are establishing a platform of knowledge and methods that offer promise for revolutionizing both models of illness pathophysiology and future diagnostic and therapeutic practice.|*Image Processing, Computer-Assisted[MESH]|*Magnetic Resonance Imaging[MESH]|*Neuropsychological Tests[MESH]|Adolescent[MESH]|Affect/physiology[MESH]|Bipolar Disorder/diagnosis/*physiopathology[MESH]|Brain Damage, Chronic/diagnosis/physiopathology[MESH]|Brain Mapping[MESH]|Brain/*physiopathology[MESH]|Child[MESH]|Cognition Disorders/diagnosis/*physiopathology[MESH]|Humans[MESH]|Nerve Net/physiopathology[MESH]|Prognosis[MESH]|Reference Values[MESH]|Research[MESH] |
