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Review Kuru and its contribution to medicine Gajdusek DCPhilos Trans R Soc Lond B Biol Sci 2008[Nov]; 363 (1510): 3697-700The solution of kuru led us to the solution of Creutzfeldt-Jakob disease and to the elucidation, in humans and other species, of previously unknown mechanisms of infection. These require very close three-dimensional matching, which determines infectious nucleant or prion activity. Evidence for nucleation processes is found widely in the organic and inorganic worlds and in the interactions between them: in the formation of amyloid fibrils; in the biochemistry of silicon; in cave formations deep in the Earth; and in outer space. Kuru in its location in Papua New Guinea has also led to an understanding of the cultural achievements of the Palaeo-Melanesians, with deep roots in human history.|Ethnicity/*ethnology[MESH]|History, 20th Century[MESH]|Humans[MESH]|Kuru/*epidemiology/*ethnology/*history[MESH]|Papua New Guinea/epidemiology[MESH]|Research/*history[MESH] |
