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l�ll Gene therapy using adeno-associated virus vectors Daya S; Berns KIClin Microbiol Rev 2008[Oct]; 21 (4): 583-93The unique life cycle of adeno-associated virus (AAV) and its ability to infect both nondividing and dividing cells with persistent expression have made it an attractive vector. An additional attractive feature of the wild-type virus is the lack of apparent pathogenicity. Gene transfer studies using AAV have shown significant progress at the level of animal models; clinical trials have been noteworthy with respect to the safety of AAV vectors. No proven efficacy has been observed, although in some instances, there have been promising observations. In this review, topics in AAV biology are supplemented with a section on AAV clinical trials with emphasis on the need for a deeper understanding of AAV biology and the development of efficient AAV vectors. In addition, several novel approaches and recent findings that promise to expand AAV's utility are discussed, especially in the context of combining gene therapy ex vivo with new advances in stem or progenitor cell biology.|*Transduction, Genetic[MESH]|Animals[MESH]|Dependovirus/*genetics/pathogenicity[MESH]|Genetic Therapy/adverse effects/*methods[MESH]|Humans[MESH] |