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Tn7 elements: engendering diversity from chromosomes to episomes Parks AR; Peters JEPlasmid 2009[Jan]; 61 (1): 1-14The bacterial transposon Tn7 maintains two distinct lifestyles, one in horizontally transferred DNA and the other in bacterial chromosomes. Access to these two DNA pools is mediated by two separate target selection pathways. The proteins involved in these pathways have evolved to specifically activate transposition into their cognate target-sites using entirely different recognition mechanisms, but the same core transposition machinery. In this review we discuss how the molecular mechanisms of Tn7-like elements contribute to their diversification and how they affect the evolution of their host genomes. The analysis of over 50 Tn7-like elements provides insight into the evolution of Tn7 and Tn7 relatives. In addition to the genes required for transposition, Tn7-like elements transport a wide variety of genes that contribute to the success of diverse organisms. We propose that by decisively moving between mobile and stationary DNA pools, Tn7-like elements accumulate a broad range of genetic material, providing a selective advantage for diverse host bacteria.|Amino Acid Sequence[MESH]|Bacteria/*genetics[MESH]|Chromosomes, Bacterial/*genetics[MESH]|DNA Transposable Elements/*genetics[MESH]|DNA-Binding Proteins/*genetics[MESH]|Molecular Sequence Data[MESH]|Phylogeny[MESH]|Plasmids/*genetics[MESH]|Sequence Alignment[MESH] |
