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Chromatin recruitment of DNA repair proteins: lessons from the fanconi anemia and double-strand break repair pathways Cohn MA; D'Andrea ADMol Cell 2008[Nov]; 32 (3): 306-12In response to DNA damage, eukaryotic cells must rapidly load DNA repair proteins onto damaged chromatin. Chromatin recruitment often entails ubiquitination of a damage-specific DNA repair protein, interaction with a ubiquitin binding factor, assembly of a multisubunit DNA repair complex, and eventually a deubiquitination event once the DNA repair reaction has been completed. This review focuses on the recent discoveries in the Fanconi Anemia (FA) and DNA double-strand break (DSB) repair pathways, which underscore the importance of regulated chromatin loading in the DNA damage response. Interestingly, these two pathways share several features, suggesting a more general mechanism for DNA-repair regulation.|*DNA Damage[MESH]|*DNA Repair[MESH]|Chromatin Assembly and Disassembly[MESH]|Chromatin/*genetics[MESH]|DNA Breaks, Double-Stranded[MESH]|Fanconi Anemia/*genetics/metabolism[MESH]|Homeostasis[MESH]|Humans[MESH]|Ubiquitin-Activating Enzymes/genetics/metabolism[MESH]|Ubiquitin/metabolism[MESH]|Ubiquitination[MESH] |
