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Repair of DNA lesions associated with triplex-forming oligonucleotides Chin JY; Glazer PMMol Carcinog 2009[Apr]; 48 (4): 389-99Triplex-forming oligonucleotides (TFOs) are gene targeting tools that can bind in the major groove of duplex DNA in a sequence-specific manner. When bound to DNA, TFOs can inhibit gene expression, can position DNA-reactive agents to specific locations in the genome, or can induce targeted mutagenesis and recombination. There is evidence that third strand binding, alone or with an associated cross-link, is recognized and metabolized by DNA repair factors, particularly the nucleotide excision repair pathway. This review examines the evidence for DNA repair of triplex-associated lesions.|*DNA Repair[MESH]|*Nucleic Acid Conformation[MESH]|Animals[MESH]|DNA Damage[MESH]|DNA/chemistry/*genetics/metabolism[MESH]|Humans[MESH]|Oligonucleotides/chemistry/*genetics/metabolism[MESH] |
