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Posttranscriptional regulation of p53 and its targets by RNA-binding proteins Zhang J; Chen XCurr Mol Med 2008[Dec]; 8 (8): 845-9p53 tumor suppressor plays a pivotal role in maintaining genomic integrity and preventing cancer development. The importance of p53 in tumor suppression is illustrated by the observation that about 50% human tumor cells have a dysfunctional p53 pathway. Although it has been well accepted that the activity of p53 is mainly controlled through post-translational modifications, recent studies have revealed that posttranscriptional regulations of p53 by various RNA-binding proteins also play a crucial role in modulating p53 activity and its downstream targets.|*Genes, p53[MESH]|Cell Cycle Proteins/genetics/metabolism[MESH]|Cyclin-Dependent Kinase Inhibitor p21/genetics/metabolism[MESH]|Humans[MESH]|Neoplasms/genetics/metabolism[MESH]|Nuclear Proteins/genetics/metabolism[MESH]|Proto-Oncogene Proteins c-mdm2/genetics/metabolism[MESH]|RNA Processing, Post-Transcriptional[MESH]|RNA, Messenger/*genetics/*metabolism[MESH]|RNA, Neoplasm/genetics/metabolism[MESH]|RNA-Binding Proteins/*metabolism[MESH]|Transcriptional Activation[MESH]|Tumor Suppressor Protein p53/metabolism[MESH] |
