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The role of infections in autoimmune disease Ercolini AM; Miller SDClin Exp Immunol 2009[Jan]; 155 (1): 1-15Autoimmunity occurs when the immune system recognizes and attacks host tissue. In addition to genetic factors, environmental triggers (in particular viruses, bacteria and other infectious pathogens) are thought to play a major role in the development of autoimmune diseases. In this review, we (i) describe the ways in which an infectious agent can initiate or exacerbate autoimmunity; (ii) discuss the evidence linking certain infectious agents to autoimmune diseases in humans; and (iii) describe the animal models used to study the link between infection and autoimmunity.|Animals[MESH]|Autoimmune Diseases/*microbiology[MESH]|Bacterial Infections/*immunology[MESH]|Disease Models, Animal[MESH]|Humans[MESH]|Models, Animal[MESH]|Parasitic Diseases/*immunology[MESH]|Virus Diseases/*immunology[MESH] |
