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Nampt: linking NAD biology, metabolism and cancer Garten A; Petzold S; Korner A; Imai S; Kiess WTrends Endocrinol Metab 2009[Apr]; 20 (3): 130-8Nicotinamide phosphoribosyltransferase (Nampt) converts nicotinamide to nicotinamide mononucleotide (NMN), a key nicotinamide adenine dinucleotide (NAD) intermediate. Previously identified as a cytokine pre-B-cell colony-enhancing factor and controversially claimed as an insulin-mimetic hormone visfatin, Nampt has recently drawn much attention in several fields, including NAD biology, metabolism and inflammation. As a NAD biosynthetic enzyme, Nampt regulates the activity of NAD-consuming enzymes such as sirtuins and influences a variety of metabolic and stress responses. Nampt also plays an important part in regulating insulin secretion in pancreatic beta-cells. Nampt seems to have another function as an immunomodulatory cytokine and, therefore, has a role in inflammation. This review summarizes these various functional aspects of Nampt and discusses its potential roles in diseases, including type 2 diabetes and cancer.|Animals[MESH]|Diabetes Mellitus, Type 2/metabolism[MESH]|Humans[MESH]|Models, Biological[MESH]|NAD/*metabolism[MESH]|Neoplasms/*metabolism[MESH]|Nicotinamide Phosphoribosyltransferase/genetics/metabolism/*physiology[MESH] |
