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Genetics of atrial fibrillation Lubitz SA; Yi BA; Ellinor PTCardiol Clin 2009[Feb]; 27 (1): 25-33, viiRecent studies of AF have identified mutations in a series of ion channels; however, these mutations appear to be relatively rare causes of AF. A genome-wide association study has identified novel variants on chromosome 4 associated with AF, although the mechanism of action for these variants remains unknown. Ultimately, a greater understanding of the genetics of AF should yield insights into novel pathways, therapeutic targets, and diagnostic testing for this common arrhythmia.|Atrial Fibrillation/*genetics[MESH]|DNA/genetics[MESH]|Genetic Linkage[MESH]|Genetic Predisposition to Disease/*genetics[MESH]|Humans[MESH]|Ion Channels/genetics[MESH]|Mutation[MESH] |