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Generation and regulation of CD8(+) regulatory T cells Lu L; Cantor HCell Mol Immunol 2008[Dec]; 5 (6): 401-6Research into the suppressive activity of CD4(+)FoxP3(+) T regulatory cells (Treg) has defined a sublineage of CD4(+) cells that contribute to self-tolerance and resistance to autoimmune disease. Much less attention has been given to the potential contribution of regulatory sublineages of CD8(+) cells. Analysis of a small fraction of CD8(+) cells that target autoreactive CD4(+) cells through recognition of the MHC class Ib molecule Qa-1 in mouse and HLA-E in human has revitalized interest in CD8(+) Treg. Here we summarize recent progress and future directions of research into the role of this CD8(+) sublineage in resistance to autoimmune disease.|Animals[MESH]|CD8-Positive T-Lymphocytes/*cytology/*immunology[MESH]|Histocompatibility Antigens Class I/immunology[MESH]|Humans[MESH]|NK Cell Lectin-Like Receptor Subfamily D/immunology[MESH] |
