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Purinergic regulation of glomerular microvasculature and tubular function Jankowski MJ Physiol Pharmacol 2008[Dec]; 59 Suppl 9 (ä): 121-35Purinergic molecules: ATP, ADP and adenosine regulate physiological processes through activation of purinoceptors in the plasma membrane. Experimental evidence supports the view that purinergic molecules affect glomerular and tubular functions. Purinergic molecule-induced changes of tension of mesangial cells and/or podocytes may influence GFR by affecting the glomerular ultrafiltration coefficient. On the other hand, purinoceptors are crucial for electrolyte and fluid homeostasis by modulating activity of sodium-potassium-ATPase, voltage-independent or -dependent ion channels and cAMP-dependent water channels.|Adenosine Diphosphate/*metabolism[MESH]|Adenosine Triphosphate/*metabolism[MESH]|Adenosine/*metabolism[MESH]|Animals[MESH]|Electrolytes/metabolism[MESH]|Glomerular Filtration Rate/physiology[MESH]|Homeostasis[MESH]|Humans[MESH]|Kidney Glomerulus/blood supply/*metabolism[MESH]|Kidney Tubules/metabolism[MESH]|Microcirculation[MESH]|Receptors, Purinergic/metabolism[MESH] |
