Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Receptor and substrate interactions of clostridial neurotoxins Brunger AT; Rummel AToxicon 2009[Oct]; 54 (5): 550-60The high potency of clostridial neurotoxins relies predominantly on their neurospecific binding and specific hydrolysis of SNARE proteins. Their multi-step mode of mechanism can be ascribed to their multi-domain three-dimensional structure. The C-terminal H(CC)-domain interacts subsequently with complex polysialo-gangliosides such as GT1b and a synaptic vesicle protein receptor via two neighbouring binding sites, resulting in highly specific uptake of the neurotoxins at synapses of cholinergic motoneurons. After its translocation the enzymatically active light chain specifically hydrolyses specific SNARE proteins, preventing SNARE complex assembly and thereby blocking exocytosis of neurotransmitter.|Animals[MESH]|Botulinum Toxins/chemistry/*metabolism/pharmacology[MESH]|Cholinergic Fibers/drug effects/metabolism[MESH]|Gangliosides/*metabolism[MESH]|Humans[MESH]|Motor Neurons/*drug effects/metabolism[MESH]|Neurotoxins/chemistry/metabolism/pharmacology[MESH]|Protein Binding[MESH]|SNARE Proteins/*drug effects/metabolism[MESH]|Structure-Activity Relationship[MESH]|Synaptic Membranes/drug effects/metabolism[MESH]|Synaptotagmins/drug effects/metabolism[MESH]|Tetanus Toxin/chemistry/*metabolism/pharmacology[MESH] |
