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lüll B cells in HIV infection and disease Moir S; Fauci ASNat Rev Immunol 2009[Apr]; 9 (4): 235-45In recent years, intense research efforts have been dedicated to elucidating the pathogenic mechanisms of HIV-associated disease progression. In addition to the progressive depletion and dysfunction of CD4(+) T cells, HIV infection also leads to extensive defects in the humoral arm of the immune system. The lack of immune control of the virus in almost all infected individuals is a great impediment to the treatment of HIV-associated disease and to the development of a successful HIV vaccine. This Review focuses on advances in our understanding of the mechanisms of B-cell dysfunction in HIV-associated disease and discusses similarities with other diseases that are associated with B-cell dysfunction.|*Disease[MESH]|Anti-Retroviral Agents/pharmacology/therapeutic use[MESH]|Antibody Formation/immunology[MESH]|B-Lymphocyte Subsets/immunology/virology[MESH]|B-Lymphocytes/*immunology/virology[MESH]|HIV Infections/etiology/*immunology/physiopathology[MESH]|Humans[MESH]|Immune System/drug effects/immunology/physiopathology[MESH]|Models, Immunological[MESH]|Viremia/drug therapy/immunology/physiopathology[MESH] |