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PGC-1alpha in aging and anti-aging interventions Anderson R; Prolla TBiochim Biophys Acta 2009[Oct]; 1790 (10): 1059-66Deregulation of mitochondrial function is a common feature in multiple aspects of aging. In addition to playing a role in aging-associated disease, decline in mitochondrial energy metabolism is likely to be important in the development of metabolic disease. Furthermore, altered mitochondrial function is a conserved feature in caloric restriction--a dietary intervention that delays aging in diverse species. The transcriptional co-activator PGC-1alpha is a critical regulator of mitochondrial energy metabolism and biogenesis. PGC-1alpha is uniquely poised as a potential target for correcting the effects of age on mitochondrial decline. We describe the cellular and tissue specific mechanisms of PGC-1alpha regulation and illustrate how these pathways may be involved in the aging process.|Aging/drug effects/genetics/*metabolism[MESH]|Animals[MESH]|Antioxidants/pharmacology[MESH]|Heat-Shock Proteins/genetics/*metabolism[MESH]|Humans[MESH]|Mitochondria/drug effects/*metabolism[MESH]|Models, Biological[MESH]|Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha[MESH]|Protein Processing, Post-Translational[MESH]|Resveratrol[MESH]|Stilbenes/pharmacology[MESH]|Transcription Factors/genetics/*metabolism[MESH] |
