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Molecular aspects of tumour hypoxia Rademakers SE; Span PN; Kaanders JH; Sweep FC; van der Kogel AJ; Bussink JMol Oncol 2008[Jun]; 2 (1): 41-53Hypoxia is an important feature of the microenvironment of a wide range of solid tumours. Its critical role in radio- and chemoresistance and its significance as an adverse prognostic factor have been well established over the last decades. On a cellular level, hypoxia evokes a complex molecular response with a central role for the HIF-1 pathway. The cellular processes under control of HIF-1 contain important prognostic information and comprise potential candidates for directing hypoxia-modifying therapies. This review will provide an overview of the current knowledge on the molecular aspects of tumour hypoxia and the link to clinical practice.|Drug Delivery Systems[MESH]|Humans[MESH]|Hypoxia-Inducible Factor 1/metabolism[MESH]|Hypoxia/drug therapy/*etiology[MESH]|Neoplasms/drug therapy/*pathology[MESH]|Prognosis[MESH] |