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lüll Lattices, rafts, and scaffolds: domain regulation of receptor signaling at the plasma membrane Lajoie P; Goetz JG; Dennis JW; Nabi IRJ Cell Biol 2009[May]; 185 (3): 381-5The plasma membrane is organized into various subdomains of clustered macromolecules. Such domains include adhesive structures (cellular synapses, substrate adhesions, and cell-cell junctions) and membrane invaginations (clathrin-coated pits and caveolae), as well as less well-defined domains such as lipid rafts and lectin-glycoprotein lattices. Domains are organized by specialized scaffold proteins including the intramembranous caveolins, which stabilize lipid raft domains, and the galectins, a family of animal lectins that cross-link glycoproteins forming molecular lattices. We review evidence that these heterogeneous microdomains interact to regulate substratum adhesion and cytokine receptor dynamics at the cell surface.|Animals[MESH]|Caveolin 1/physiology[MESH]|Cell Adhesion/physiology[MESH]|Cell Membrane/*physiology[MESH]|Coated Pits, Cell-Membrane/physiology[MESH]|Membrane Microdomains/*physiology[MESH]|Receptors, Antigen, T-Cell/physiology[MESH]|Receptors, Cell Surface/physiology[MESH]|Signal Transduction/*physiology[MESH] |