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Typical 2-Cys peroxiredoxins--structures, mechanisms and functions Hall A; Karplus PA; Poole LBFEBS J 2009[May]; 276 (9): 2469-77Peroxiredoxins are abundant cellular antioxidant proteins that help to control intracellular peroxide levels. These proteins may also function, in part, through an evolved sensitivity of some peroxiredoxins towards peroxide-mediated inactivation in hydrogen peroxide signaling in eukaryotes. This review summarizes recent progress in our understanding of the catalytic and regulatory mechanisms of 'typical 2-Cys' peroxiredoxins and of the biological roles played by these important enzymes in oxidative stress and nonstress-related cellular signaling. New evidence suggests localized peroxide buildup plays a role in nonstress-related signaling.|Animals[MESH]|Catalysis[MESH]|Cysteine/*chemistry/metabolism[MESH]|Humans[MESH]|Hydrogen Peroxide/metabolism[MESH]|Models, Biological[MESH]|Models, Molecular[MESH]|Oxidative Stress[MESH]|Peroxiredoxins/*chemistry/*metabolism[MESH]|Signal Transduction[MESH]|Structure-Activity Relationship[MESH] |
