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Common vs rare allele hypotheses for complex diseases Schork NJ; Murray SS; Frazer KA; Topol EJCurr Opin Genet Dev 2009[Jun]; 19 (3): 212-9There has been growing debate over the nature of the genetic contribution to individual susceptibility to common complex diseases such as diabetes, osteoporosis, and cancer. The 'Common Disease, Common Variant (CDCV)' hypothesis argues that genetic variations with appreciable frequency in the population at large, but relatively low 'penetrance' (or the probability that a carrier of the relevant variants will express the disease), are the major contributors to genetic susceptibility to common diseases. The 'Common Disease, Rare Variant (CDRV)' hypothesis, on the contrary, argues that multiple rare DNA sequence variations, each with relatively high penetrance, are the major contributors to genetic susceptibility to common diseases. Both hypotheses have their place in current research efforts.|Alleles[MESH]|Base Sequence[MESH]|Gene Frequency[MESH]|Genetic Predisposition to Disease/*genetics[MESH]|Genetic Variation/*genetics[MESH]|Genome-Wide Association Study[MESH]|Humans[MESH]|Molecular Sequence Data[MESH]|Mutation[MESH]|Phenotype[MESH] |
