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The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencing Eulalio A; Tritschler F; Izaurralde ERNA 2009[Aug]; 15 (8): 1433-42GW182 family proteins interact directly with Argonaute proteins and are required for miRNA-mediated gene silencing in animal cells. The domains of the GW182 proteins have recently been studied to determine their role in silencing. These studies revealed that the middle and C-terminal regions function as an autonomous domain with a repressive function that is independent of both the interaction with Argonaute proteins and of P-body localization. Such findings reinforce the idea that GW182 proteins are key components of miRNA repressor complexes in metazoa.|*Gene Silencing[MESH]|Amino Acid Sequence[MESH]|Animals[MESH]|Autoantigens/*chemistry/genetics/*metabolism[MESH]|Binding Sites/genetics[MESH]|Caenorhabditis elegans Proteins/chemistry/genetics/metabolism[MESH]|Conserved Sequence[MESH]|Drosophila Proteins/chemistry/genetics/metabolism[MESH]|Eukaryotic Initiation Factors/metabolism[MESH]|Humans[MESH]|MicroRNAs/*genetics/*metabolism[MESH]|Models, Genetic[MESH]|Models, Molecular[MESH]|Molecular Sequence Data[MESH]|Protein Structure, Tertiary[MESH]|RNA Processing, Post-Transcriptional[MESH]|RNA-Binding Proteins[MESH]|Sequence Homology, Amino Acid[MESH] |
