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The treatment of wet age-related macular degeneration Joussen AM; Bornfeld NDtsch Arztebl Int 2009[May]; 106 (18): 312-7BACKGROUND: Age-related macular degeneration (AMD) is a progressive disease affecting the macula, the area of the retina that has the highest visual acuity. It can progress to geographic atrophy or choroidal neovascularization. METHOD: Selective literature review. RESULTS: The authors discuss the results of therapeutic trials and the treatment recommendations of the ophthalmological societies. Mechanism-targeted treatments and improved modes of administration offer the potential for improved therapy. CONCLUSIONS: With the advent of the antivascular endothelial growth factor (anti-VEGF) therapy, the prognosis of choroidal neovascularization has changed dramatically. Visual acuity can actually be improved, but, in most cases, the improvement can only be sustained with repeated intravitreal injections.|Angiogenesis Inhibitors/*administration & dosage[MESH]|Choroidal Neovascularization/*complications/*therapy[MESH]|Humans[MESH]|Light Coagulation/*trends[MESH]|Macular Degeneration/*complications/*therapy[MESH]|Photochemotherapy/*trends[MESH] |
