Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
BH3-only proteins in apoptosis and beyond: an overview Lomonosova E; Chinnadurai GOncogene 2008[Dec]; 27 Suppl 1 (Suppl 1): S2-19BH3-only BCL-2 family proteins are effectors of canonical mitochondrial apoptosis. They discharge their pro-apoptotic functions through BH1-3 pro-apoptotic proteins such as BAX and BAK, while their activity is suppressed by BH1-4 anti-apoptotic BCL-2 family members. The precise mechanism by which BH3-only proteins mediate apoptosis remains unresolved. The existing data are consistent with three mutually non-exclusive models (1) displacement of BH1-3 proteins from complexes with BH1-4 proteins; (2) direct interaction with and conformational activation of BH1-3 proteins; and (3) membrane insertion and membrane remodeling. The BH3-only proteins appear to play critical roles in restraining cancer and inflammatory diseases such as rheumatoid arthritis. Molecules that mimic the effect of BH3-only proteins are being used in treatments against these diseases. The cell death activity of a subclass of BH3-only members (BNIP3 and BNIP3L) is linked to cardiomyocyte loss during heart failure. In addition to their established role in apoptosis, several BH3-only members also regulate diverse cellular functions in cell-cycle regulation, DNA repair and metabolism. Several members are implicated in the induction of autophagy and autophagic cell death, possibly through unleashing of the BH3-only autophagic effector Beclin 1 from complexes with BCL-2/BCL-xL. The Chapters included in the current Oncogene Review issues provide in-depth discussions on various aspects of major BH3-only proteins.|Amino Acid Sequence[MESH]|Animals[MESH]|Antineoplastic Agents/pharmacology/therapeutic use[MESH]|Apoptosis Regulatory Proteins/chemistry/genetics/*physiology[MESH]|Apoptosis/drug effects/*physiology[MESH]|Arthritis, Rheumatoid/metabolism[MESH]|Autophagy/physiology[MESH]|Caenorhabditis elegans Proteins/physiology[MESH]|Cell Cycle/physiology[MESH]|Cell Transformation, Neoplastic[MESH]|Consensus Sequence/*physiology[MESH]|Gene Expression Regulation[MESH]|Heart Failure/metabolism/pathology[MESH]|Humans[MESH]|Mammals/metabolism[MESH]|Mice[MESH]|Mitochondrial Membranes/metabolism[MESH]|Molecular Sequence Data[MESH]|Multigene Family[MESH]|Peptide Fragments/chemistry/*physiology[MESH]|Protein Conformation[MESH]|Protein Interaction Mapping[MESH]|Protein Structure, Tertiary[MESH]|Proto-Oncogene Proteins c-bcl-2/chemistry/*physiology[MESH]|Proto-Oncogene Proteins/chemistry/*physiology[MESH] |
