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Virotherapy against malignant glioma stem cells Dey M; Ulasov IV; Lesniak MSCancer Lett 2010[Mar]; 289 (1): 1-10Glioblastoma multiforme, the most common primary intracranial malignancy, is associated with very poor outcome despite advances in surgical techniques and chemo- and radiation therapy. Many novel treatment modalities are being investigated with varying amount of success. Evolution of cancer stem cell hypothesis provides a new venue for developmental therapeutics. In this review, we highlight the literature regarding the existence of glioma stem cells and their characteristics. We also discuss the potential for virotherapy, a novel therapeutic approach utilizing conditionally replicative viruses, to directly target this population of self-renewing cancer stem cells.|*Oncolytic Virotherapy/trends[MESH]|Cell Proliferation[MESH]|Glioma/*therapy/virology[MESH]|Humans[MESH]|Neoplasm Staging[MESH]|Neoplastic Stem Cells/*cytology/*virology[MESH]|Virus Replication[MESH] |