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T cells in mycobacterial infection and disease Cooper AMCurr Opin Immunol 2009[Aug]; 21 (4): 378-84There has been an increase in our understanding of the complexity of the T cell response to mycobacterial infection recently. Improved tools have allowed the determination of the location and kinetics of naive T cell activation in the mouse as well the variety of function of mycobacteria-specific cells in humans. There is also an increased appreciation of the balance required during mycobacterial infection between anti-bacterial activity and control of the immunopathologic response. The integration of the T cell functional data with the consequences of infection should improve rational vaccine design.|Animals[MESH]|Cytokines/immunology[MESH]|Humans[MESH]|Lung/immunology/microbiology/pathology[MESH]|Mice[MESH]|Mycobacterium tuberculosis/growth & development/*immunology/pathogenicity[MESH]|Phagocytes/*immunology/microbiology/pathology[MESH]|T-Lymphocyte Subsets/*immunology/microbiology/pathology[MESH]|T-Lymphocytes, Regulatory/*immunology/microbiology/pathology[MESH]|Tuberculosis Vaccines/therapeutic use[MESH]|Tuberculosis, Pulmonary/*immunology/pathology/therapy[MESH]|Virulence[MESH] |
