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Role of protein tyrosine nitration in neurodegenerative diseases and atherosclerosis Lee JR; Kim JK; Lee SJ; Kim KPArch Pharm Res 2009[Aug]; 32 (8): 1109-18Nitric oxide generates reactive nitrosative species, such as peroxynitrite (ONOO(-)) that may be involved in a number of diseases. ONOO(-) can mediate protein tyrosine nitration which causes structural changes of affected proteins and leads to their inactivation. Various proteomics and immunological methods including mass spectrometry combined with both liquid and 2-D PAGE, and immunodetection have been employed to identify and characterize nitrated proteins from pathological samples. This review presents the pahtobiological roles of the pathogenic posttranslational modification in neurodegenerative diseases and atherosclerosis.|Animals[MESH]|Atherosclerosis/*etiology/metabolism[MESH]|CD40 Ligand/physiology[MESH]|Cardiovascular Diseases/etiology/metabolism[MESH]|Humans[MESH]|Neurodegenerative Diseases/*etiology/metabolism[MESH]|Nitric Oxide/*metabolism[MESH]|Protein Processing, Post-Translational[MESH]|Proteins/*metabolism[MESH]|Proteomics[MESH]|Receptors, LDL/physiology[MESH]|Tyrosine/*metabolism[MESH] |
