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Dendritic cells in intestinal homeostasis and disease Rescigno M; Di Sabatino AJ Clin Invest 2009[Sep]; 119 (9): 2441-50DCs are specialized APCs that orchestrate innate and adaptive immune responses. The intestinal mucosa contains numerous DCs, which induce either protective immunity to infectious agents or tolerance to innocuous antigens, including food and commensal bacteria. Several subsets of mucosal DCs have been described that display unique functions, dictated in part by the local microenvironment. In this review, we summarize the distinct subtypes of DCs and their distribution in the gut; examine how DC dysfunction contributes to intestinal disease development, including inflammatory bowel disease and celiac disease; and discuss manipulation of DCs for therapy.|Animals[MESH]|Celiac Disease/etiology/immunology/therapy[MESH]|Dendritic Cells/classification/*immunology[MESH]|Homeostasis[MESH]|Humans[MESH]|Immunity, Innate[MESH]|Immunity, Mucosal[MESH]|Immunosuppression Therapy[MESH]|Inflammatory Bowel Diseases/etiology/immunology/therapy[MESH]|Intestinal Diseases/*etiology/immunology/therapy[MESH]|Intestines/cytology/*immunology[MESH]|Lymphocyte Activation[MESH]|Models, Immunological[MESH] |
