Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression Wasch R; Robbins JA; Cross FROncogene 2010[Jan]; 29 (1): 1-10Deregulation of the G1/G0 phase of the cell cycle can lead to cancer. During G1, most cells commit alternatively to DNA replication and division, or to cell-cycle exit and differentiation. The anaphase-promoting complex or cyclosome (APC/C) activated by Cdh1 coordinately eliminates positive cell-cycle regulators as well as inhibitors of differentiation, thereby coupling cell-cycle exit and differentiation. Misregulation of Cdh1 thus has the potential to promote both cell-cycle re-entry and either perturbed differentiation or dedifferentiation. In addition, APC/C(Cdh1) is required to maintain genomic stability. As a result, loss of Cdh1 can contribute to tumorigenesis in the form of proliferation of poorly differentiated and genetically unstable cells.|*Genomic Instability[MESH]|Anaphase-Promoting Complex-Cyclosome[MESH]|Animals[MESH]|Cell Cycle Proteins/metabolism/*physiology[MESH]|Cell Cycle/physiology[MESH]|Cell Differentiation/*physiology[MESH]|Cell Proliferation[MESH]|Humans[MESH]|Models, Biological[MESH]|Neoplasms/genetics/pathology/*physiopathology[MESH]|Ubiquitin-Protein Ligase Complexes/*metabolism[MESH] |
