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Interleukin-21 in T cell-mediated diseases Monteleone G; Sarra M; Pallone FDiscov Med 2009[Oct]; 8 (42): 113-7Interleukin-21 (IL-21), a cytokine produced by activated CD4+ T cells, activated natural killer T cells, and T follicular cells, has been reported to play a crucial role in the tissue-damaging T cell response in various organs, such as gut, skin, pancreas, and joints. This pathogenic effect is strictly linked to the ability of IL-21 to enhance the functional activities of multiple immune and non-immune cells. Consistently, studies from various laboratories have shown that blockade of IL-21 limits the progression of T cell-mediated inflammatory diseases in mice. Here we review the present knowledge on the expression and role of IL-21 in T cell-mediated pathologies.|Animals[MESH]|Autoimmunity/immunology[MESH]|Humans[MESH]|Inflammation/immunology/metabolism[MESH]|Interleukin-21[MESH]|Interleukins/*immunology/metabolism[MESH]|Mice[MESH]|T-Lymphocytes/*immunology/metabolism[MESH] |