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The role of B cells in lupus pathogenesis Nashi E; Wang Y; Diamond BInt J Biochem Cell Biol 2010[Apr]; 42 (4): 543-50Autoantibodies clearly contribute to tissue inflammation in systemic lupus erythematosus. In order to therapeutically target B cells making pathogenic autoantibodies, it is necessary to identify their phenotype. It is also important to understand the defects in B cell repertoire selection that permit pathogenic autoreactive B cells to enter the immunocompetent B cell repertoire. We present the data that both marginal zone and follicular B cells can produce pathogenic autoantibodies. Moreover, we discuss how B cell survival and maturation are regulated centrally prior to antigen activation and in the periphery after antigen activation to form the repertoire that generates the spectrum of circulating antibodies.|Animals[MESH]|Autoantibodies/immunology[MESH]|B-Cell Activating Factor/metabolism[MESH]|B-Lymphocyte Subsets/immunology/*metabolism/pathology[MESH]|B-Lymphocytes/immunology/*metabolism/pathology[MESH]|Estrogens/metabolism[MESH]|Humans[MESH]|Immune Tolerance[MESH]|Lupus Erythematosus, Systemic/immunology/*pathology[MESH]|Receptors, Antigen, B-Cell/*metabolism[MESH]|Signal Transduction/*immunology[MESH]|Toll-Like Receptors/metabolism[MESH] |
