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GSK3: a multifaceted kinase in Wnt signaling Wu D; Pan WTrends Biochem Sci 2010[Mar]; 35 (3): 161-8GSK3 is one of the few signaling mediators that play central roles in a diverse range of signaling pathways, including those activated by Wnts, hedgehog, growth factors, cytokines, and G protein-coupled ligands. Although the inhibition of GSK3-mediated beta-catenin phosphorylation is known to be the key event in Wnt-beta-catenin signaling, the mechanisms that underlie this event remain incompletely understood. The recent demonstration of GSK3 involvement in Wnt receptor phosphorylation illustrates the multifaceted roles that GSK3 plays in Wnt-beta-catenin signaling. In this review, we will summarize these recent results and offer explanations, hypotheses, and models to reconcile some of these observations.|Animals[MESH]|Glycogen Synthase Kinase 3/genetics/*metabolism[MESH]|LDL-Receptor Related Proteins/metabolism[MESH]|Protein Isoforms/metabolism[MESH]|Signal Transduction/*physiology[MESH]|Wnt Proteins/genetics/*metabolism[MESH]|beta Catenin/genetics/metabolism[MESH] |
